A large randomised controlled intervention trial to prevent gastric cancer by eradication of Helicobacter pylori in Linqu County, China: baseline results and factors affecting the eradication.
19065
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A large randomised controlled intervention trial to prevent gastric cancer by eradication of Helicobacter pylori in Linqu County, China: baseline results and factors affecting the eradication.

发表时间：2015-05-22 14:48

编辑于 14:48h 学术成果, 研究论文

 

ABSTRACT

Objective To clarify the full range of benefits and adverse consequences of Helicobacter pylori eradication as a strategy for gastric cancer prevention, the community-based intervention trial was launched in Linqu County, China.Design A total of 184 786 residents aged 25–54 years were enrolled in this trial and received 13 C-urea breath test. H. pylori positive participants were assigned into two groups, either receiving a 10-day quadruple anti-H. pylori treatment or lookalike placebos together with a single dosage of omeprazole and bismuth.Results The prevalence of H. pylori in trial participants was 57.6%. A total of 94 101 subjects completed the treatment. The overall H. pylori eradication rate was 72.9% in the active group. Gender, body mass index,history of stomach disease, baseline delta over baseline value of 13 C-urea breath test, missed medication doses,smoking and drinking were independent predictors of eradication failure. The missed doses and high baseline delta over baseline-value were important contributors in men and women (all P trend <0.001). However, a dose response relationship between failure rate and smoking or drinking index was found in men (all P trend <0.001),while high body mass index (P trend <0.001) and history of stomach disease were significant predictors in women.The treatment failure rate increased up to 48.8% (OR 2.87, 95% CI 2.24 to 3.68) in men and 39.4% (OR 2.67, 95% CI 1.61 to 4.42) in women with multiple factors combined.Conclusions This large community-based intervention trial to eradicate H. pylori is feasible and acceptable.The findings of this trial lead to a distinct evaluation of factors influencing eradication that should be generally considered for future eradication therapies.Trial registration number ChiCTR-TRC-10000979 in accordance with WHO ICTRP requirements.

第一署名医院：北京大学肿瘤医院