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发表时间:2013-12-18 13:23

Antiangiogenesistherapyhasshednewlightoncancertreatment,butitseffectiveness,especiallyforoverall patient survival, is still controversial. Here, we show that antiangiogenesis treatment causes a persistent suppression of mitochondria biogenesis in colorectal cancer cells, which renders them more sensitive to glycolytic...

发表时间:2013-12-18 13:11

Using genome-wide promoter methylation analysis, we identified a disintegrin-like and metalloprotease with thrombospondin type 1 motif 9 (ADAMTS9) is methylated in cancer. We aim to clarify its epigenetic inactivation, biological function and clinical implication in gastric cancer. ADAMTS9 was silenced in 6 out of 8...

发表时间:2013-12-18 09:37

Objective Loss of surface maturation and cytonuclear atypia have been regarded as the pathological ‘gold standard’ for the diagnosis of oesophageal squamous cell intraepithelial neoplasia. However, there has been no satisfactory endomicroscopic method similar to this pathological approach to detect surface maturation and screen for...

发表时间:2013-12-17 13:22

An 8-year-old boy was admitted to our hospital due to intermittent episodes of dysphagia over the past 5 years, which was severely affecting his physical growth and quality of life. He was diagnosed as having achalasia 3 years ago, and had twice undergone endoscopic balloon...